TREATING C3 GLOMERULOPATHY WITH ECULIZUMAB

Treating C3 glomerulopathy with eculizumab

Abstract Background C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis.The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pathway of the complement cascade.Currently, there is no established therapy.Treatment with the C5 complement inhibitor eculi

read more

Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes

The Japanese wild-derived mouse strain MSM/Ms (MSM) mackie mixer 16 channel retains a wide range of traits related to behavioral wildness, including high levels of emotionality and avoidance of humans.In this study, we observed that MSM showed a markedly higher level of aggression than the standard laboratory strain C57BL/6J.Whereas almost all MSM

read more

A novel asynchronous access method with binary interfaces

Abstract Background Traditionally synchronous access strategies require users to bullet bill shirt comply with one or more time constraints in order to communicate intent with a binary human-machine interface (e.g., mechanical, gestural or neural switches).Asynchronous access methods are preferable, but have not been used with binary interfaces in

read more


The Translated Amino Acid Sequence of an Insertion in the Hepatitis E Virus Strain 47832c Genome, But Not the RNA Sequence, Is Essential for Efficient Cell Culture Replication

The hepatitis E virus (HEV) can cause hepatitis E in humans.Recently, the occurrence of HEV strains carrying insertions in their hypervariable genome region has been described in chronically infected patients.The insertions originate from human genes or from the HEV genome itself.Although their distinct functions are largely unknown, an involvement

read more